CINECA IRIS Institutional Research Information System
IRIS è la soluzione IT che facilita la raccolta e la gestione dei dati relativi alle attività e ai prodotti della ricerca. Fornisce a ricercatori, amministratori e valutatori gli strumenti per monitorare i risultati della ricerca, aumentarne la visibilità e allocare in modo efficace le risorse disponibili.
EnglishHistorically, many useful drugs have been developed from natural sources and their mechanisms of action deeply investigated for therapeutic applications. Recently, the interaction between pharmacologically active biomolecules and transition metal ions has opened the way to the construction of new drugs, where the unique properties of metal complexes are combined with the specific mechanisms of action of the coordinated bioligands of natural extraction. In this context, this perspective summarizes some recent research studies devoted to the development of new metal-based drugs containing Zn(II) or Cu(II) metal ions. Both metals have a strong tendency to form highly stable complexes with N,N- and O,O-donor ligands bound through chelation, giving rise, particularly when the bound organic molecules are drug candidates of natural extraction, to drug delivery systems, new biologically active complexes and potential diagnostic agents due to their intrinsic spectroscopic properties.
Scheda prodotto non validato
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo
| Titolo: | Zn(II) and Cu(II) Complexes Containing Bioactive O,O-Chelated Ligands: Homoleptic and Heteroleptic Metal-Based Biomolecules |
| Autori: | |
| Data di pubblicazione: | 2015 |
| Rivista: | |
| Handle: | http://hdl.handle.net/20.500.11770/144597 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
http://hdl.handle.net/20.500.11770/144597
Copyright © 2021