A three-functional nanocomposite was prepared by radical polymerization of methacrylic acid aroundcarbon nanotubes in the presence of Quercetin as biologically active molecule and proposed as new anticancertherapeutic. The so-obtained hybrid material was characterized by FT-IR, Raman, SEM, TEM analyses,while the functionalization degree of 2.33 mg of Quercetin per g of composite was assessed byFolin–Ciocalteu test. Antioxidant test (DPPH and ABTS) showed that the covalent coupling did not interferewith the antioxidant properties of the flavonoid, while the anticancer activity was greatly enhancedwith a recorded IC50 value much lower than free Quercetin. Cell viability tests on healthy cells demonstratedno-toxicity of the conjugate
Quercetin nanocomposite as novel anticancer therapeutic: improved efficiency and reduced toxicity
Cirillo, G;Iemma, F;Puoci F;Picci, N
2013-01-01
Abstract
A three-functional nanocomposite was prepared by radical polymerization of methacrylic acid aroundcarbon nanotubes in the presence of Quercetin as biologically active molecule and proposed as new anticancertherapeutic. The so-obtained hybrid material was characterized by FT-IR, Raman, SEM, TEM analyses,while the functionalization degree of 2.33 mg of Quercetin per g of composite was assessed byFolin–Ciocalteu test. Antioxidant test (DPPH and ABTS) showed that the covalent coupling did not interferewith the antioxidant properties of the flavonoid, while the anticancer activity was greatly enhancedwith a recorded IC50 value much lower than free Quercetin. Cell viability tests on healthy cells demonstratedno-toxicity of the conjugateI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
