The efficient design of a membrane bioreactor for cells culture needs the complete characterization — bothexperimentally and theoretically — of the transport phenomena for metabolites, catabolites, cell regulatory andimmune-related soluble factors. In this work, experiments and theoretical calculations have been carried out in orderto discern the simultaneous influence of both diffusive and convective mechanisms to the transport of metabolites.In particular, the transmembrane mass flux of glucose, bovine serum albumin (BSA), apotransferrin andimmunoglobulin G was experimentally measured, under pressure and concentration gradients, through high-fluxmicroporous hydrophilic poly-ether-sulphone (PES-HFMs) and poly-sulphone hollow fiber membranes (PS-HFMs).
Diffusive and convective transport in HF membrane reactors for biomedical applications
CURCIO, EFREM
;
2006-01-01
Abstract
The efficient design of a membrane bioreactor for cells culture needs the complete characterization — bothexperimentally and theoretically — of the transport phenomena for metabolites, catabolites, cell regulatory andimmune-related soluble factors. In this work, experiments and theoretical calculations have been carried out in orderto discern the simultaneous influence of both diffusive and convective mechanisms to the transport of metabolites.In particular, the transmembrane mass flux of glucose, bovine serum albumin (BSA), apotransferrin andimmunoglobulin G was experimentally measured, under pressure and concentration gradients, through high-fluxmicroporous hydrophilic poly-ether-sulphone (PES-HFMs) and poly-sulphone hollow fiber membranes (PS-HFMs).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
