A high-yielding reaction protocol for the microwave-assisted organocatalytic conjugate addition of diethyl malonate to enones under solvent-free conditions is proposed. The method still permits the use of cheap and commercially available L-proline furnishing very good performance at least in the case of 1-alkyl-3-monosubstituted enones.
A New Microwave-Assisted Organocatalytic Solvent-Free Synthesis of Optically Enriched Michael Adducts / DE NINO, Antonio; Procopio, A; Nardi, M; Oliverio, M; Paonessa, R; Pasceri, R.. - In: SYNLETT. - ISSN 0936-5214. - 12(2010), pp. 1849-1853.
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Titolo: | A New Microwave-Assisted Organocatalytic Solvent-Free Synthesis of Optically Enriched Michael Adducts |
Autori: | |
Data di pubblicazione: | 2010 |
Rivista: | |
Citazione: | A New Microwave-Assisted Organocatalytic Solvent-Free Synthesis of Optically Enriched Michael Adducts / DE NINO, Antonio; Procopio, A; Nardi, M; Oliverio, M; Paonessa, R; Pasceri, R.. - In: SYNLETT. - ISSN 0936-5214. - 12(2010), pp. 1849-1853. |
Handle: | http://hdl.handle.net/20.500.11770/152274 |
Appare nelle tipologie: | 1.1 Articolo in rivista |