A high-yielding reaction protocol for the microwave-assisted organocatalytic conjugate addition of diethyl malonate to enones under solvent-free conditions is proposed. The method still permits the use of cheap and commercially available L-proline furnishing very good performance at least in the case of 1-alkyl-3-monosubstituted enones.
A New Microwave-Assisted Organocatalytic Solvent-Free Synthesis of Optically Enriched Michael Adducts
DE NINO, Antonio;
2010-01-01
Abstract
A high-yielding reaction protocol for the microwave-assisted organocatalytic conjugate addition of diethyl malonate to enones under solvent-free conditions is proposed. The method still permits the use of cheap and commercially available L-proline furnishing very good performance at least in the case of 1-alkyl-3-monosubstituted enones.File in questo prodotto:
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