The p53 family member TAp73 is a transcription factor that plays akey role in many biological processes, including neuronal development.In particular, wehave shown that p73 drives the expression ofmiR-34a, but not miR-34b and c, in mouse cortical neurons. miR-34ain turn modulates the expression of synaptic targets includingsynaptotagmin-1 and syntaxin-1A. Here we show that this axis is retainedin mouse ES cells committed to differentiate toward a neurologicalphenotype. Moreover, overexpression of miR-34a altershippocampal spinal morphology, and results in electrophysiologicalchanges consistent with a reduction in spinal function. Therefore,the TAp73/miR-34a axis has functional relevance in primary neurons.These data reinforce a role for miR-34a in neuronal development.
microRNA-34a regulates neurite outgrowth, spinal morphology, and function
Tucci P.;
2011-01-01
Abstract
The p53 family member TAp73 is a transcription factor that plays akey role in many biological processes, including neuronal development.In particular, wehave shown that p73 drives the expression ofmiR-34a, but not miR-34b and c, in mouse cortical neurons. miR-34ain turn modulates the expression of synaptic targets includingsynaptotagmin-1 and syntaxin-1A. Here we show that this axis is retainedin mouse ES cells committed to differentiate toward a neurologicalphenotype. Moreover, overexpression of miR-34a altershippocampal spinal morphology, and results in electrophysiologicalchanges consistent with a reduction in spinal function. Therefore,the TAp73/miR-34a axis has functional relevance in primary neurons.These data reinforce a role for miR-34a in neuronal development.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
