A series of chalcones (1–9) and pyrazoles (10–18) was prepared to investigate their potential activity asAngiotensin I-Converting Enzyme (ACE) inhibitors. Their structures were verified by elemental analysis,UV, IR, MS, 1H NMR, 13C NMR, and 2D NMR experiments. Among tested compounds, chalcone 7 exertedthe highest activity with an IC50 value of 0.219 mM, while the most potent pyrazole was 15 (IC50 value of0.213 mM).
The synthesis and Angiotensin Converting Enzyme (ACE) inhibitory activity of chalcones and their pyrazole derivatives
Marco, Bonesi;Loizzo, Monica Rosa;Statti, Giancarlo;
2010-01-01
Abstract
A series of chalcones (1–9) and pyrazoles (10–18) was prepared to investigate their potential activity asAngiotensin I-Converting Enzyme (ACE) inhibitors. Their structures were verified by elemental analysis,UV, IR, MS, 1H NMR, 13C NMR, and 2D NMR experiments. Among tested compounds, chalcone 7 exertedthe highest activity with an IC50 value of 0.219 mM, while the most potent pyrazole was 15 (IC50 value of0.213 mM).File in questo prodotto:
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