Mitochondrial DNA haplogroups and APOE4 allele are non-independent variables in sporadic Alzheimer's disease

The impressive performance of the research in biology of mitochondrion has greatly improved our knowledge on the functions of this organelle and highlighted the influence its functioning has on numerous human phenotypes. In particular, many studies have focused on the involvement of mitochondrion function (and dysfunction) in human ageing. To date, the literature in this specific field of mitochondrial biology is so vast that it is often difficult to properly put new data and new findings in the right context. The present paper aims to review the findings of the last few years in order to outline a general framework to understand how mitochondria can affect ageing and how ageing affects mitochondria.