Extracts, linariin, isolinariin A and B obtained from Linaria reflexa Desf. (Scrophulariaceae) were tested foracetylcholinesterase inhibition activity using Ellman’s method. A dose-response relationship was observed for all extracts andisolated compounds. Flavones exhibited IC50 values ranging from 0.27 μM to 0.30 μM. The structure-activity relationship wasbriefly discussed.

Acetyl-cholinesterase inhibition by extracts and isolated flavones from Linaria reflexa Desf. (Scrophulariaceae)

LOIZZO, Monica Rosa;TUNDIS, ROSA;Bonesi M;STATTI, Giancarlo;
2007

Abstract

Extracts, linariin, isolinariin A and B obtained from Linaria reflexa Desf. (Scrophulariaceae) were tested foracetylcholinesterase inhibition activity using Ellman’s method. A dose-response relationship was observed for all extracts andisolated compounds. Flavones exhibited IC50 values ranging from 0.27 μM to 0.30 μM. The structure-activity relationship wasbriefly discussed.
Linaria reflexa Desf.; Flavones; Acetyl-cholinesterase (AChE)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11770/155014
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