Tertiary a-hydroxyalkynes undergo oxidative carbonylation in alcohols in the presence of catalytic amounts of Pd12- KI to give (3-lactones derived from alkoxycarbonylation at the terminal carbon of the alkyne and cis-carbonylation at the internal carbon, followed by carbonyl trapping by the tertiary hydroxy group.
Stereoselective synthesis of beta-lactones containing alpha-Z-alkoxycarbonylmethylene chains by palladium-catalysed oxidative carbonylation of tertiary alfa-hydroxyalkynes
GABRIELE, Bartolo;
1994-01-01
Abstract
Tertiary a-hydroxyalkynes undergo oxidative carbonylation in alcohols in the presence of catalytic amounts of Pd12- KI to give (3-lactones derived from alkoxycarbonylation at the terminal carbon of the alkyne and cis-carbonylation at the internal carbon, followed by carbonyl trapping by the tertiary hydroxy group.File in questo prodotto:
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