The antioxidant and anti-cholinesterase properties of Globularia meridionalis (Podp.) O. Schwarz (Globulariaceae) were herein investigated. G. meridionalis aerial parts and roots were extracted with methanol. The total extract was successively partitioned with n-hexane. The roots methanol fraction showed the highest antioxidant activity with IC50 values of 8.0 and 2.1 microg/mL on DPPH test and beta-carotene bleaching test, respectively. From this fraction three flavonoids namely pectolinarigenin 7-O-beta-glucoside, apigenin 7-O-beta-glucoside and luteolin, and two phenylethanoids namely acteoside and isoacteoside were isolated. Potential anti-cholinesterase effects were assessed through the acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes inhibition assay. The n-hexane fraction of the roots exhibited the highest activity against both AChE and BChE with IC50 values of 65.5 and 70.4 microg/mL, respectively.
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Titolo: | Antioxidant and anti-cholinesterase activity of Globularia meridionalis (Podp.) O. Schwarz extracts and isolated constituents |
Autori: | |
Data di pubblicazione: | 2012 |
Rivista: | |
Handle: | http://hdl.handle.net/20.500.11770/159707 |
Appare nelle tipologie: | 1.1 Articolo in rivista |