Chiral cyclopentenones are important precursors in the asymmetric synthesis of target molecules. In particular, C- 2 amino cyclopentenones could be utilised as intermediates towards antitumor natural products. (a) On the basis of our previous experience (b) we report an environmental friendly protocol for the synthesis in water of bifunctionalised cyclopentenones. The use of water and MW (c) give high regioselectivity and good to excellent yields. The reaction can be realized in short time with various nucleophiles
Aqueous microwave-assisted synthesis of 4,5 or 2,4 bifunctionalised cyclopentenones
P. Costanzo;A. De Nino;DI GIOIA, Maria Luisa;F. Olivito;
2016-01-01
Abstract
Chiral cyclopentenones are important precursors in the asymmetric synthesis of target molecules. In particular, C- 2 amino cyclopentenones could be utilised as intermediates towards antitumor natural products. (a) On the basis of our previous experience (b) we report an environmental friendly protocol for the synthesis in water of bifunctionalised cyclopentenones. The use of water and MW (c) give high regioselectivity and good to excellent yields. The reaction can be realized in short time with various nucleophilesFile in questo prodotto:
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