A new strategy for the synthesis of tetrahydroisoquinolines based on the Pd0-catalyzed intramolecular a-arylation of sulfones is reported. The combination of this Pd-catalyzed reaction with intermolecular Michael and aza-Michael reactions allows the development of two- and three-step domino processes to synthesize diversely functionalized scaffolds from readily available starting materials.
Pd0-catalyzed intramolecular α-arylation of sulfones: Domino reactions in the synthesis of functionalized tetrahydroisoquinolines
Mancuso, Raffaella
2015-01-01
Abstract
A new strategy for the synthesis of tetrahydroisoquinolines based on the Pd0-catalyzed intramolecular a-arylation of sulfones is reported. The combination of this Pd-catalyzed reaction with intermolecular Michael and aza-Michael reactions allows the development of two- and three-step domino processes to synthesize diversely functionalized scaffolds from readily available starting materials.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
