A new strategy for the synthesis of tetrahydroisoquinolines based on the Pd0-catalyzed intramolecular a-arylation of sulfones is reported. The combination of this Pd-catalyzed reaction with intermolecular Michael and aza-Michael reactions allows the development of two- and three-step domino processes to synthesize diversely functionalized scaffolds from readily available starting materials.

Pd0-catalyzed intramolecular α-arylation of sulfones: Domino reactions in the synthesis of functionalized tetrahydroisoquinolines

Mancuso, Raffaella
2015

Abstract

A new strategy for the synthesis of tetrahydroisoquinolines based on the Pd0-catalyzed intramolecular a-arylation of sulfones is reported. The combination of this Pd-catalyzed reaction with intermolecular Michael and aza-Michael reactions allows the development of two- and three-step domino processes to synthesize diversely functionalized scaffolds from readily available starting materials.
Arylation; Domino reactions; Nitrogen heterocycles; Palladium; Sulfones; Aza Compounds; Catalysis; Palladium; Sulfones; Tetrahydroisoquinolines; Chemistry (all)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11770/264938
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