Selenoprotein T (SelT or SELENOT) is a novel thioredoxin-like enzyme whose genetic ablation in mice results in early embryonic lethality. SelT exerts an essential cytoprotective action during development and after injury through its redox-active catalytic site. The present study aims to determine the expression and regulation of SelT in the mammalian heart in normal and pathological conditions, and to evaluate the cardioprotective effect of a SelT-derived peptide, SelT43-52(PSELT) encompassing the redox motif which is key to its function, against ischemia/reperfusion(I/R) injury.

A selenoprotein T-derived peptide protects the heart against ischemia/reperfusion injury through inhibition of apoptosis and oxidative stress

Rocca, Carmine;Granieri, Maria Concetta;Mazza, Rosa;Tota, Bruno;Cerra, Maria Carmela;Angelone, Tommaso
2018-01-01

Abstract

Selenoprotein T (SelT or SELENOT) is a novel thioredoxin-like enzyme whose genetic ablation in mice results in early embryonic lethality. SelT exerts an essential cytoprotective action during development and after injury through its redox-active catalytic site. The present study aims to determine the expression and regulation of SelT in the mammalian heart in normal and pathological conditions, and to evaluate the cardioprotective effect of a SelT-derived peptide, SelT43-52(PSELT) encompassing the redox motif which is key to its function, against ischemia/reperfusion(I/R) injury.
2018
Heart; RISK pathways; apoptosis; peptide; post-conditioning; redox activity
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Descrizione: This is the pre-peer reviewed version of the following article: [Rocca C, Boukhzar L, Granieri MC, Alsharif I, Mazza R, Lefranc B, Tota B, Leprince J, Cerra MC, Anouar Y, Angelone T. A selenoprotein T-derived peptide protects the heart against ischaemia/reperfusion injury through inhibition of apoptosis and oxidative stress. Acta Physiol (Oxf). 2018 Aug;223(4):e13067. doi: 10.1111/apha.13067. Epub 2018 Apr 17. PMID: 29575758.], which has been published in final form at [https://doi.org/10.1111/apha.13067]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11770/278727
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