Titanium tetrachloride has been successfully used in the benzylation of aromatic substrates with a series of benzyl alcohols under mild reaction conditions. With monosubstituted aromatic substrates, ortho and para-substituted products are obtained in almost comparable amounts. With sterically hindered benzyl alcohol derivatives almost exclusively para-substitution occurs.

Titanium tetrachloride-mediated synthesis of diarylmethanes through the reaction of benzyl alcohol derivatives with aromatic substrates

Leggio, Antonella
;
Belsito, Emilia Lucia;
2018

Abstract

Titanium tetrachloride has been successfully used in the benzylation of aromatic substrates with a series of benzyl alcohols under mild reaction conditions. With monosubstituted aromatic substrates, ortho and para-substituted products are obtained in almost comparable amounts. With sterically hindered benzyl alcohol derivatives almost exclusively para-substitution occurs.
Aromatic substrates; Benzyl alcohol; Diarylmethanes; Friedel crafts reactions; Substituted benzyl alcohols; Titanium tetrachloride; Organic Chemistry
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/20.500.11770/290048
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