Enantioselective Vinylogous Reactions of 3-Alkylidene Oxindoles

Oxindoles represent an important class of bioactive compounds and synthetic derivatives found in many natural products. Most of these compounds are chiral molecules and the challenge of their asymmetric synthesis has fascinated many research groups. In particular, the creation of chiral centers out of the oxindole ring by vinylogous addition to 3-alkylidene-substituted oxindoles (3-alkylidene-1,3-dihydro-2 H -indol-2-ones) has emerged in recent years. This review aims to give an overview of this topic. 1 Introduction 2 Aldol and Mannich Reactions 3 Addition to Unsaturated Carbonyl Compounds 4 Addition to Nitroalkenes 5 Miscellaneous 6 Conclusion.