Four new monomeric pyrophosphate complexes, namely [Co(phen) 2(H 2P 2O 7)]̇4H 2O (1'4H 2O), [Ni(phen) 2(H 2P 2O 7)]'8H 2O (2'8H 2O), [Cu(phen)(H 2O)(H 2P 2O 7)] (3) and [Cu(phen)(H 2O)(P 2O 7)][Na 2(H 2O) 8]'6H 2O (4'14H 2O) have been isolated and structurally characterized. The impact of pH and stoichiometry in obtaining 1-4 is described. These complexes have been tested against the adriamycin-resistant ovarian cancer cell line A2780/AD, revealing highly significant (nM) IC 50 values, compared to μM IC 50 values for cisplatin controls. © 2010 American Chemical Society.

Expanding monomeric pyrophosphate complexes beyond platinum

Marino, Nadia;
2010

Abstract

Four new monomeric pyrophosphate complexes, namely [Co(phen) 2(H 2P 2O 7)]̇4H 2O (1'4H 2O), [Ni(phen) 2(H 2P 2O 7)]'8H 2O (2'8H 2O), [Cu(phen)(H 2O)(H 2P 2O 7)] (3) and [Cu(phen)(H 2O)(P 2O 7)][Na 2(H 2O) 8]'6H 2O (4'14H 2O) have been isolated and structurally characterized. The impact of pH and stoichiometry in obtaining 1-4 is described. These complexes have been tested against the adriamycin-resistant ovarian cancer cell line A2780/AD, revealing highly significant (nM) IC 50 values, compared to μM IC 50 values for cisplatin controls. © 2010 American Chemical Society.
Antineoplastic Agents; Cell Line, Tumor; Diphosphates; Humans; Inhibitory Concentration 50; Models, Molecular; Molecular Conformation; Organometallic Compounds; Platinum; Physical and Theoretical Chemistry; Inorganic Chemistry
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11770/292767
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 14
  • ???jsp.display-item.citation.isi??? 14
social impact