The hydroamination reaction is a convenient alternative strategy for the formation of C– N bonds. Herein, we report a new versatile and convenient protocol for the hydroamination of arylacetylenes with anilines using palladium iodide in the absence of any added ligand as catalyst. Mild conditions, excellent regio- and stereoselectivity, and high functional group tolerance are the main features of this methodology. A subsequent reduction step gives access to a wide variety of secondary aromatic amines

PdI2 as a Simple and Efficient Catalyst for the Hydroamination of Arylacetylenes with Anilines

Mancuso, R.;Gabriele, B.;
2020-01-01

Abstract

The hydroamination reaction is a convenient alternative strategy for the formation of C– N bonds. Herein, we report a new versatile and convenient protocol for the hydroamination of arylacetylenes with anilines using palladium iodide in the absence of any added ligand as catalyst. Mild conditions, excellent regio- and stereoselectivity, and high functional group tolerance are the main features of this methodology. A subsequent reduction step gives access to a wide variety of secondary aromatic amines
2020
hydroamination; palladium; secondary amines; imines
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11770/298620
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