Graphene quantum dots, the next generation carbon based nanomaterials, due to their outstanding physical, chemical and biological properties, have shown potential in revolutionizing the future of nanomedicine and biotechnology. Their strong size-dependent photoluminescence (PL) and the presence of reactive groups on the GQD surface, which allow their multimodal conjugation with various functional groups and biologically active molecules, make them ideal candidates for cancer diagnosis and treatment. GQDs have been loaded with drugs and labeled with tumor-targeting ligand units that are able to specifically recognize cancer receptors exposed on the cancer cell surface by generating new therapies that are able to allow a more efficient targeted delivery of anticancer agents while minimizing their distribution in healthy tissues, as well as the development of new imaging agents for the in vitro and in vivo diagnosis of several types of cancer. Here, we review the recent advances in the study of the application of GQDs as nanoplatforms for anticancer therapy, taking into account the methods used for their synthesis and functionalization procedures, which can deeply affect their biocompatibility and their electronic and optical features. The biosafety and toxicity aspects of these nanomaterials at cellular and animal levels, mainly related to their size and the kind and degree of surface functionalization, are also discussed.

Graphene quantum dots: Multifunctional nanoplatforms for anticancer therapy

Ziccarelli I.;
2017

Abstract

Graphene quantum dots, the next generation carbon based nanomaterials, due to their outstanding physical, chemical and biological properties, have shown potential in revolutionizing the future of nanomedicine and biotechnology. Their strong size-dependent photoluminescence (PL) and the presence of reactive groups on the GQD surface, which allow their multimodal conjugation with various functional groups and biologically active molecules, make them ideal candidates for cancer diagnosis and treatment. GQDs have been loaded with drugs and labeled with tumor-targeting ligand units that are able to specifically recognize cancer receptors exposed on the cancer cell surface by generating new therapies that are able to allow a more efficient targeted delivery of anticancer agents while minimizing their distribution in healthy tissues, as well as the development of new imaging agents for the in vitro and in vivo diagnosis of several types of cancer. Here, we review the recent advances in the study of the application of GQDs as nanoplatforms for anticancer therapy, taking into account the methods used for their synthesis and functionalization procedures, which can deeply affect their biocompatibility and their electronic and optical features. The biosafety and toxicity aspects of these nanomaterials at cellular and animal levels, mainly related to their size and the kind and degree of surface functionalization, are also discussed.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/20.500.11770/299002
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 85
  • ???jsp.display-item.citation.isi??? 85
social impact