Chromogranin A (CgA), a 439-residue long protein, is an important cardiovascular regulator and a precursor of various bio-active fragments. Under stressful/pathological conditions, CgA cleavage generates the CgA1-373 proangiogenic fragment. The present work investigated the possibility that human CgA1-373 influences the mammalian cardiac performance, evaluating the role of its C-terminal sequence.
The chromogranin A1-373 fragment reveals how a single change in the protein sequence exerts strong cardioregulatory effects by engaging neuropilin-1
Rocca, Carmine;Grande, Fedora;Granieri, Maria Concetta;De Bartolo, Anna;Giordano, Francesca;Rago, Vittoria;Cerra, Maria Carmela;Angelone, Tommaso
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2021-01-01
Abstract
Chromogranin A (CgA), a 439-residue long protein, is an important cardiovascular regulator and a precursor of various bio-active fragments. Under stressful/pathological conditions, CgA cleavage generates the CgA1-373 proangiogenic fragment. The present work investigated the possibility that human CgA1-373 influences the mammalian cardiac performance, evaluating the role of its C-terminal sequence.File in questo prodotto:
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