Chromogranin A (CgA), a 439-residue long protein, is an important cardiovascular regulator and a precursor of various bio-active fragments. Under stressful/pathological conditions, CgA cleavage generates the CgA1-373 proangiogenic fragment. The present work investigated the possibility that human CgA1-373 influences the mammalian cardiac performance, evaluating the role of its C-terminal sequence.
Rocca, Carmine;Grande, Fedora;Granieri, Maria Concetta;De Bartolo, Anna;Giordano, Francesca;Rago, Vittoria;Cerra, Maria Carmela;Angelone, Tommaso
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