Chromogranin A (CgA), a 439-residue long protein, is an important cardiovascular regulator and a precursor of various bio-active fragments. Under stressful/pathological conditions, CgA cleavage generates the CgA1-373 proangiogenic fragment. The present work investigated the possibility that human CgA1-373 influences the mammalian cardiac performance, evaluating the role of its C-terminal sequence.

The chromogranin A1-373 fragment reveals how a single change in the protein sequence exerts strong cardioregulatory effects by engaging neuropilin-1

Rocca, Carmine;Grande, Fedora;Granieri, Maria Concetta;De Bartolo, Anna;Giordano, Francesca;Rago, Vittoria;Cerra, Maria Carmela;Angelone, Tommaso
;
2021-01-01

Abstract

Chromogranin A (CgA), a 439-residue long protein, is an important cardiovascular regulator and a precursor of various bio-active fragments. Under stressful/pathological conditions, CgA cleavage generates the CgA1-373 proangiogenic fragment. The present work investigated the possibility that human CgA1-373 influences the mammalian cardiac performance, evaluating the role of its C-terminal sequence.
2021
Chromogranin A
Heart
Intracellular signaling
Neuropilin-1
Nitric oxide
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11770/308574
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