Alzheimer’s Disease (AD) accounts for approximately 50% of dementia cases worldwide and the linked agitation, the most challenging neuropsychiatric symptom, is tightly associated with under-treated pain states. Essential oils able to provide analgesia are needed to afford a safe treatment of pain with consequent efficacy on agitation. The essential oil of bergamot (BEO) proved effective in preclinical models of nociceptive and neuropathic pain. The aim of the present study is to review the pharmacological properties of BEO accounting for its translational activity in chronic pain and in agitation due to dementia.

Essential oils-induced analgesia and related translation for the management of agitation in dementia

Damiana Scuteri;Giacinto Bagetta
;
Maria Tiziana Corasaniti
2022

Abstract

Alzheimer’s Disease (AD) accounts for approximately 50% of dementia cases worldwide and the linked agitation, the most challenging neuropsychiatric symptom, is tightly associated with under-treated pain states. Essential oils able to provide analgesia are needed to afford a safe treatment of pain with consequent efficacy on agitation. The essential oil of bergamot (BEO) proved effective in preclinical models of nociceptive and neuropathic pain. The aim of the present study is to review the pharmacological properties of BEO accounting for its translational activity in chronic pain and in agitation due to dementia.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/20.500.11770/337203
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