Patients with chronic lymphocytic leukemia carrying a single TP53 hit (chromosome 17p deletion or single TP53 mutation) demonstrate excellent progression-free survival and overall survival on ibrutinib compared with cases harboring multiple TP53 hits. Testing TP53 deletion/mutation combining FISH and deep nextgeneration sequencing should be performed for a correct patient evaluation.
TP53 Disruption in Chronic Lymphocytic Leukemia Under Ibrutinib: More is Worse?
Gentile, Massimo;
2021-01-01
Abstract
Patients with chronic lymphocytic leukemia carrying a single TP53 hit (chromosome 17p deletion or single TP53 mutation) demonstrate excellent progression-free survival and overall survival on ibrutinib compared with cases harboring multiple TP53 hits. Testing TP53 deletion/mutation combining FISH and deep nextgeneration sequencing should be performed for a correct patient evaluation.File in questo prodotto:
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