CLL is frequently complicated by autoimmune phenomena (up to 25% of patients) which are sustained by dysfunctions of the immune system. AIHA results the commonest form. In the past decade small molecules had dramatically change the therapeutic scenario of CLL. Their role in the setting of autoimmune phenomena has to be still elucidated. Here we report the case of a CLL patient harboring del (17p) in relapse of disease during ibrutinib therapy who experienced AIHA. Patient, refractory to steroids, achieved benefit from the administration of rituximab and venetoclax. The patient reached stable and long-lasting stabilization of hemoglobin values.
Autoimmune Hemolytic Anemia in Chronic Lymphocytic Leukemia Successfully Treated with Rituximab-Venetoclax: A Case Report
Vigna E;Gentile M;
2021-01-01
Abstract
CLL is frequently complicated by autoimmune phenomena (up to 25% of patients) which are sustained by dysfunctions of the immune system. AIHA results the commonest form. In the past decade small molecules had dramatically change the therapeutic scenario of CLL. Their role in the setting of autoimmune phenomena has to be still elucidated. Here we report the case of a CLL patient harboring del (17p) in relapse of disease during ibrutinib therapy who experienced AIHA. Patient, refractory to steroids, achieved benefit from the administration of rituximab and venetoclax. The patient reached stable and long-lasting stabilization of hemoglobin values.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
