OBJECTIVE: To evaluate the relationship between plasma leptin and the tumor necrosis factor-α (TNFα), TNF receptor p60 (TNF-R1) and TNF receptor p80 (TNF-R2) concentrations in obese subjects. DESIGN: Case-control study. SETTING: Outpatient's Service for Prevention and Treatment of Obesity at the University Hospital. MEASUREMENTS: Body mass index (BMI), waist circumference, hip circumference, waist-to-hip ratio (WHR), fasting plasma glucose, fasting plasma insulin, homeostasis model assessment of insulin resistance (HOMA IR), plasma leptin, TNFα, TNF-R1 and TNF-R2 concentrations were evaluated in obese subjects (n = 42) and in age- and gender-matched, lean healthy controls (n = 16). RESULTS: In obese subjects, fasting plasma glucose and insulin, HOMA IR, plasma leptin, TNFα, TNF-R1 and TNF-R2 concentrations were significantly higher than in controls. Furthermore, females showed higher leptin, TNF-R1 and TNF-R2 plasma concentrations compared to males, in both control and obese subjects. In control subjects, plasma leptin concentrations showed a direct correlation with BMI (r = 0.74, P < 0.001), hip circumference (r = 0.94, P < 0.001), TNF-R1 (r = 0.79, P < 0.001) and TNF-R2 (r = 0.64, P < 0.01), and a negative correlation with WHR (r = -0.58, P < 0.05). In obese subjects, we found a direct correlation between plasma leptin concentrations and BMI (r = 0.67, P < 0.001), hip circumference (r = 0.66, P < 0.001), fasting glucose (r = 0.37, P < 0.05), fasting insulin (r = 0.31, P < 0.05), HOMA IR (r = 0.38, P < 0.05), TNF-R1 (r = 0.71, P < 0.001) and TNR-R2 (r = 0.66, P < 0.001), while a negative correlation was found between circulating leptin and WHR (r = -0.44, P < 0.01). In multivariate analysis, plasma leptin concentrations were significantly associated with BMI (P = 0.015) and gender (P = 0.047) in the control group, while in obese subjects, plasma leptin showed a significant association with BMI (P = 0.019) and TNF-R1 (P = 0.012). CONCLUSIONS: Our results are consistent with the hypothesis that the TNFα system could be involved in the regulation of plasma leptin concentrations in obese subjects.

Relationship between plasma leptin levels and the tumor necrosis factor-α system in obese subjects

Corsonello, A.;Calapai, G.;
1999-01-01

Abstract

OBJECTIVE: To evaluate the relationship between plasma leptin and the tumor necrosis factor-α (TNFα), TNF receptor p60 (TNF-R1) and TNF receptor p80 (TNF-R2) concentrations in obese subjects. DESIGN: Case-control study. SETTING: Outpatient's Service for Prevention and Treatment of Obesity at the University Hospital. MEASUREMENTS: Body mass index (BMI), waist circumference, hip circumference, waist-to-hip ratio (WHR), fasting plasma glucose, fasting plasma insulin, homeostasis model assessment of insulin resistance (HOMA IR), plasma leptin, TNFα, TNF-R1 and TNF-R2 concentrations were evaluated in obese subjects (n = 42) and in age- and gender-matched, lean healthy controls (n = 16). RESULTS: In obese subjects, fasting plasma glucose and insulin, HOMA IR, plasma leptin, TNFα, TNF-R1 and TNF-R2 concentrations were significantly higher than in controls. Furthermore, females showed higher leptin, TNF-R1 and TNF-R2 plasma concentrations compared to males, in both control and obese subjects. In control subjects, plasma leptin concentrations showed a direct correlation with BMI (r = 0.74, P < 0.001), hip circumference (r = 0.94, P < 0.001), TNF-R1 (r = 0.79, P < 0.001) and TNF-R2 (r = 0.64, P < 0.01), and a negative correlation with WHR (r = -0.58, P < 0.05). In obese subjects, we found a direct correlation between plasma leptin concentrations and BMI (r = 0.67, P < 0.001), hip circumference (r = 0.66, P < 0.001), fasting glucose (r = 0.37, P < 0.05), fasting insulin (r = 0.31, P < 0.05), HOMA IR (r = 0.38, P < 0.05), TNF-R1 (r = 0.71, P < 0.001) and TNR-R2 (r = 0.66, P < 0.001), while a negative correlation was found between circulating leptin and WHR (r = -0.44, P < 0.01). In multivariate analysis, plasma leptin concentrations were significantly associated with BMI (P = 0.015) and gender (P = 0.047) in the control group, while in obese subjects, plasma leptin showed a significant association with BMI (P = 0.019) and TNF-R1 (P = 0.012). CONCLUSIONS: Our results are consistent with the hypothesis that the TNFα system could be involved in the regulation of plasma leptin concentrations in obese subjects.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11770/344487
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 116
  • ???jsp.display-item.citation.isi??? 113
social impact