In elderly patients with nonthyroidal illnesses (NTI), a reduction in T3 plasma concentrations and an increase in reverse T3 (rT3) levels are frequently observed. This condition is usually referred to as "low T3 syndrome", "sick euthyroid syndrome" (SES), or "nonthyroidal illness syndrome". The pathophysiology and the clinical significance of this syndrome are still largely unknown. In this review of the literature, we focused on the putative role of cytokines (such as tumor necrosis factor-α, interleukin-6, transforming growth factor-β1 and others) as mediators of the SES. Finally, the interpretation and clinical significance of the syndrome, and its therapeutic approach is discussed.
The sick euththyroid syndrome (SES): Focusing on the role of cytokines
Corsonello, A.;
2002-01-01
Abstract
In elderly patients with nonthyroidal illnesses (NTI), a reduction in T3 plasma concentrations and an increase in reverse T3 (rT3) levels are frequently observed. This condition is usually referred to as "low T3 syndrome", "sick euthyroid syndrome" (SES), or "nonthyroidal illness syndrome". The pathophysiology and the clinical significance of this syndrome are still largely unknown. In this review of the literature, we focused on the putative role of cytokines (such as tumor necrosis factor-α, interleukin-6, transforming growth factor-β1 and others) as mediators of the SES. Finally, the interpretation and clinical significance of the syndrome, and its therapeutic approach is discussed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
