In elderly patients with nonthyroidal illnesses (NTI), a reduction in T3 plasma concentrations and an increase in reverse T3 (rT3) levels are frequently observed. This condition is usually referred to as "low T3 syndrome", "sick euthyroid syndrome" (SES), or "nonthyroidal illness syndrome". The pathophysiology and the clinical significance of this syndrome are still largely unknown. In this review of the literature, we focused on the putative role of cytokines (such as tumor necrosis factor-α, interleukin-6, transforming growth factor-β1 and others) as mediators of the SES. Finally, the interpretation and clinical significance of the syndrome, and its therapeutic approach is discussed.

The sick euththyroid syndrome (SES): Focusing on the role of cytokines

Corsonello, A.;
2002-01-01

Abstract

In elderly patients with nonthyroidal illnesses (NTI), a reduction in T3 plasma concentrations and an increase in reverse T3 (rT3) levels are frequently observed. This condition is usually referred to as "low T3 syndrome", "sick euthyroid syndrome" (SES), or "nonthyroidal illness syndrome". The pathophysiology and the clinical significance of this syndrome are still largely unknown. In this review of the literature, we focused on the putative role of cytokines (such as tumor necrosis factor-α, interleukin-6, transforming growth factor-β1 and others) as mediators of the SES. Finally, the interpretation and clinical significance of the syndrome, and its therapeutic approach is discussed.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11770/344497
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