Objectives: The aggressive surgical strategy adopted for vulvar cancer is related to ahigh complication rate, usually consisting in infections and wound breakdown.Considering that platelet gel concentrate improves reparation of cutaneous lesions, theaim of the current retrospective study was to evaluate the efficacy of platelet gelapplication in women who had undergone radical surgery for vulvar cancer.Methods/Materials: We retrospectively analyzed record charts of 25 women referred toour Academic Departments with a diagnosis of vulvar cancer and who had undergoneradical vulvectomy plus inguinofemoral lymphanedectomy between January 2007 andDecember 2011. During the reconstructive phase, a platelet gel was placed on thevaginal breach, in ten women (Group A). In the remnant 15 patients, only surgicalstrategies were performed (Group B). Primary outcomes were wound infection,necrosis and/or breakdown of wounds rates; secondary outcomes were post-operativefever, hospital stay and lastly the wound healing.Results: Compared to surgery alone, the platelet gel application was related to asignificant decrease in wound infection (P=0.032), necrosis of vaginal wounds(P=0.096) and breakdown wound (P=0.048) rates. In addition, in group A reduction inpostoperative fever rate (P<0.001) and hospital stay (P<0.001) were also detected.Compared to surgery alone, a faster wound healing in patients who had undergonesurgery plus platelet (P<0.001) were lastly observed.Conclusions: Platelet gel application before vulvar reconstruction represents aneffective strategy in order to prevent wound breakdown after local advanced vulvarcancer surgery. However, further prospective data are needed in order to confirmthese preliminary results.
Adjuvant Use of Platelet Gel for Wound Breakdown Prevention in Advanced Vulvar Cancer Surgery A Retrospective Study
Morelli M;
2013-01-01
Abstract
Objectives: The aggressive surgical strategy adopted for vulvar cancer is related to ahigh complication rate, usually consisting in infections and wound breakdown.Considering that platelet gel concentrate improves reparation of cutaneous lesions, theaim of the current retrospective study was to evaluate the efficacy of platelet gelapplication in women who had undergone radical surgery for vulvar cancer.Methods/Materials: We retrospectively analyzed record charts of 25 women referred toour Academic Departments with a diagnosis of vulvar cancer and who had undergoneradical vulvectomy plus inguinofemoral lymphanedectomy between January 2007 andDecember 2011. During the reconstructive phase, a platelet gel was placed on thevaginal breach, in ten women (Group A). In the remnant 15 patients, only surgicalstrategies were performed (Group B). Primary outcomes were wound infection,necrosis and/or breakdown of wounds rates; secondary outcomes were post-operativefever, hospital stay and lastly the wound healing.Results: Compared to surgery alone, the platelet gel application was related to asignificant decrease in wound infection (P=0.032), necrosis of vaginal wounds(P=0.096) and breakdown wound (P=0.048) rates. In addition, in group A reduction inpostoperative fever rate (P<0.001) and hospital stay (P<0.001) were also detected.Compared to surgery alone, a faster wound healing in patients who had undergonesurgery plus platelet (P<0.001) were lastly observed.Conclusions: Platelet gel application before vulvar reconstruction represents aneffective strategy in order to prevent wound breakdown after local advanced vulvarcancer surgery. However, further prospective data are needed in order to confirmthese preliminary results.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
