Special Issue “Mitochondrial Metabolism Alterations in Health and Disease”

Mitochondria are central hubs of cellular metabolism and signaling that play key roles in stress response, inflammation, calcium homeostasis, mitochondrial quality control, and cell death, with mitochondrial impairment potentially being the underlying cause of several conditions, including metabolic, neurodegenerative, and cardiovascular diseases. Furthermore, mitochondrial dysfunction can contribute to the hallmarks of cancer, including sustained proliferative signaling, resistance to cell death, and altered cellular energetics. Therefore, analyzing the mechanisms underlying mitochondrial dysfunction and developing targeted therapies to restore mitochondrial function have become essential research areas. This Special Issue offers an outstanding collection of up-to-date reviews and research articles focusing on mitochondria and their potential for fighting human diseases.