Abstract: Wendtia calycina (Griseb.) Griseb., Vivianiaceae, is a Paraguayan herbaceous plant commonly known as burrito. Our previous study indicated that burrito leaves are a very good source of phenylpropanoid glycosides, principally verbascoside. From W. calycina leaves, a standardized, water-soluble extract rich in phenylpropanoid glycosides (WSE) has been developed on an industrial scale to be used as a food supplement, cosmetic, phytomedicine, and ingredient of different formulations. In this study, we investigated the effect of the WSE on human platelet aggregation in vitro induced by adenosine diphosphate (ADP), epinephrine (EPN), collagen (COL) or arachidonic acid (AA). WSE, concentration-dependently, inhibited ADP and EP-induced human platelet aggregation (IC50 were 0.82±0.15 mg/mL and 0.41±0.02 mg/mL, respectively). It did not inhibit collagen-induced platelet aggregation, thus suggesting a selectivity for the ADP-induced platelet activation pathways.
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|Titolo:||Inhibition of human platelet aggregation in vitro by standardized extract of Wendtia calycina|
|Data di pubblicazione:||2011|
|Citazione:||Inhibition of human platelet aggregation in vitro by standardized extract of Wendtia calycina / GARCIA MESA, M.; Piccinelli, A; Valiente, M. A.; Pinto, A; Fazio, Alessia; Rastrelli, L.. - In: REVISTA BRASILEIRA DE FARMACOGNOSIA. - ISSN 0102-695X. - 21:5(2011), pp. 884-888.|
|Appare nelle tipologie:||1.1 Articolo in rivista|