Spherical Molecularly Imprinted Polymers (SMIPs) via a novel precipitation Polymerization in the Controlled delivery of Sulfasalazine

Spherical molecularly imprinted polymers (SMIPs) have been prepared via a novel precipitation polymerization using sulfasalazine (prodrug used in the diseases of the colon) as template. The sulfasalazine was incorporated into SMIPs and into a spherical non-imprinted polymer (control), and then the release rate of the bioactive agent at different pH values was evaluated. Considerable differences in the release characteristics between imprinted and nonimprinted polymers have been observed. This opens the possibility of the development of drug release systems capable of modulating the release of a specific molecule.

Spherical Molecularly Imprinted Polymers (SMIPs) via a novel precipitation Polymerization in the Controlled delivery of Sulfasalazine / Puoci, F; Iemma, F; Muzzalupo, R; Spizzirri, Ug; Trombino, Sonia; Cassano, R; Picci, N. - In: MACROMOLECULAR BIOSCIENCE. - ISSN 1616-5187. - 4(2004), pp. 22-26.



Titolo: Spherical Molecularly Imprinted Polymers (SMIPs) via a novel precipitation Polymerization in the Controlled delivery of Sulfasalazine
Autori: 
PUOCI, Francesco
IEMMA, Francesca
MUZZALUPO, Rita
SPIZZIRRI, Umile Gianfranco
TROMBINO, Sonia
CASSANO, Roberta
PICCI, Nevio
Data di pubblicazione: 2004
Rivista: 
MACROMOLECULAR BIOSCIENCE  
Citazione: Spherical Molecularly Imprinted Polymers (SMIPs) via a novel precipitation Polymerization in the Controlled delivery of Sulfasalazine / Puoci, F; Iemma, F; Muzzalupo, R; Spizzirri, Ug; Trombino, Sonia; Cassano, R; Picci, N. - In: MACROMOLECULAR BIOSCIENCE. - ISSN 1616-5187. - 4(2004), pp. 22-26.
Handle: http://hdl.handle.net/20.500.11770/128942
Appare nelle tipologie:1.1 Articolo in rivista

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http://hdl.handle.net/20.500.11770/128942
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