Spherical molecularly imprinted polymers (SMIPs) have been prepared via a novel precipitation polymerization using sulfasalazine (prodrug used in the diseases of the colon) as template. The sulfasalazine was incorporated into SMIPs and into a spherical non-imprinted polymer (control), and then the release rate of the bioactive agent at different pH values was evaluated. Considerable differences in the release characteristics between imprinted and nonimprinted polymers have been observed. This opens the possibility of the development of drug release systems capable of modulating the release of a specific molecule.

Spherical Molecularly Imprinted Polymers (SMIPs) via a novel precipitation Polymerization in the Controlled delivery of Sulfasalazine

Puoci F;IEMMA F;MUZZALUPO R;Spizzirri UG;TROMBINO Sonia;CASSANO R;Picci N
2004

Abstract

Spherical molecularly imprinted polymers (SMIPs) have been prepared via a novel precipitation polymerization using sulfasalazine (prodrug used in the diseases of the colon) as template. The sulfasalazine was incorporated into SMIPs and into a spherical non-imprinted polymer (control), and then the release rate of the bioactive agent at different pH values was evaluated. Considerable differences in the release characteristics between imprinted and nonimprinted polymers have been observed. This opens the possibility of the development of drug release systems capable of modulating the release of a specific molecule.
drug delivery systems, environmental sensitive polymers, molecular imprinting, precipitation polymerization, sulfasalazine
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/20.500.11770/128942
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 7
  • Scopus 96
  • ???jsp.display-item.citation.isi??? 91
social impact