A simple and economical synthesis of substituted furans and pyrroles, by ligand-free CuCl2-catalyzed heterocyclodehydrationof readily available 3-yne-1,2-diols and N-Boc- or N-tosyl-1-amino-3-yn-2-ols,respectively, is presented. Reactions are carried out in MeOH at 80–100 C for 1–24 h and afford the correspondingheterocyclic derivatives in 53–99% isolated yields.
A simple and convenient synthesis of substituted furans and pyrroles by CuCl2-catalyzed heterocyclodehydration of 3-yne-1,2-diols and N-Boc- or N-tosyl-1-amino-3-yn-2-ols
Gabriele B.;Plastina P.;Veltri L.;Mancuso R.;
2010-01-01
Abstract
A simple and economical synthesis of substituted furans and pyrroles, by ligand-free CuCl2-catalyzed heterocyclodehydrationof readily available 3-yne-1,2-diols and N-Boc- or N-tosyl-1-amino-3-yn-2-ols,respectively, is presented. Reactions are carried out in MeOH at 80–100 C for 1–24 h and afford the correspondingheterocyclic derivatives in 53–99% isolated yields.File in questo prodotto:
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