Polymer-supported thiol 5 was prepared and used in the cleavage of N-nosyl groups from protected α-amino acids. Thus, the polymer-supported thiol 5 was prepared from 4,4′-dimeth-oxytrityl chloride 1 and Wang resin (three steps). Deprotection of N-nosyl-α-amino acids 6 was carried out with 5 and DBU to give the corresponding amines 7.
Deprotection of the N-Nosyl Group with a Thiol Resin
DI GIOIA, Maria Luisa;Leggio A;LIGUORI, Angelo;
2009-01-01
Abstract
Polymer-supported thiol 5 was prepared and used in the cleavage of N-nosyl groups from protected α-amino acids. Thus, the polymer-supported thiol 5 was prepared from 4,4′-dimeth-oxytrityl chloride 1 and Wang resin (three steps). Deprotection of N-nosyl-α-amino acids 6 was carried out with 5 and DBU to give the corresponding amines 7.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
