(Z)-(2-En-4-ynyl)amines 1 bearing an internal triple bond undergo smooth cycloisomerization into pyrroles 2 in thepresence of catalytic amounts of PdCl2 in conjunction with KCl at 25–100°C in anhydrous N,N-dimethylacetamide. When thetriple bond is terminal, spontaneous uncatalyzed cyclization to the corresponding pyrroles takes place. © 2001 Elsevier ScienceLtd. All rights reserved.
Palladium-catalyzed cycloisomerization of (Z)-(2-en-4-ynyl)amines: a new synthesis of substituted pyrroles
GABRIELE, Bartolo
;FAZIO, Alessia;
2001-01-01
Abstract
(Z)-(2-En-4-ynyl)amines 1 bearing an internal triple bond undergo smooth cycloisomerization into pyrroles 2 in thepresence of catalytic amounts of PdCl2 in conjunction with KCl at 25–100°C in anhydrous N,N-dimethylacetamide. When thetriple bond is terminal, spontaneous uncatalyzed cyclization to the corresponding pyrroles takes place. © 2001 Elsevier ScienceLtd. All rights reserved.File in questo prodotto:
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