A novel and convenient approach to furan-3-carboxylic esters 2 is presented, based on palladium-catalyzed direct oxidative carbonylation of readily available 3-yne-1,2-diols 1. The process, correspondingto a sequential combination between a 5-endo-dig heterocyclodehydration step and an oxidative alkoxycarbonylation stage, is catalyzed by PdI2 in conjunction with an excess of KI under relatively mild conditions(100 °C in ROH under 40 atm of a 4:1 mixture of CO-air).

Palladium-catalyzed oxidative heterocyclodehydration-alkoxycarbonylation of 3-yne-1,2-diols: a novel and expedient approach to furan-3-carboxylic esters

Gabriele B.;Veltri L.;Mancuso R.;Plastina P.;
2010-01-01

Abstract

A novel and convenient approach to furan-3-carboxylic esters 2 is presented, based on palladium-catalyzed direct oxidative carbonylation of readily available 3-yne-1,2-diols 1. The process, correspondingto a sequential combination between a 5-endo-dig heterocyclodehydration step and an oxidative alkoxycarbonylation stage, is catalyzed by PdI2 in conjunction with an excess of KI under relatively mild conditions(100 °C in ROH under 40 atm of a 4:1 mixture of CO-air).
2010
Furans; Carbonylation; Palladium; Heterocycles
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11770/137934
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