An unprecedented, PdI2-catalyzed, sequential oxidative aminocarbonylation-cyclocarbonylation process, leading to 2-oxazolidinone derivatives3 in good to excellent yields starting from readily available r,r-disubstituted 2-ynylamines 1 and secondary amines 2, is reported. In the caseof an r-monosubstituted substrate, the initially formed 2-oxazolidinone derivative underwent shift of the double bond to give a 3H-oxazol-2-one derivative in excellent isolated yield.
An Unprecedented Pd-Catalyzed, Water-Promoted Sequential Oxidative Aminocarbonylation – Cyclocarbonylation Process Leading to 2-Oxazolidinones
GABRIELE, Bartolo;PLASTINA, Pierluigi;MANCUSO R;
2007-01-01
Abstract
An unprecedented, PdI2-catalyzed, sequential oxidative aminocarbonylation-cyclocarbonylation process, leading to 2-oxazolidinone derivatives3 in good to excellent yields starting from readily available r,r-disubstituted 2-ynylamines 1 and secondary amines 2, is reported. In the caseof an r-monosubstituted substrate, the initially formed 2-oxazolidinone derivative underwent shift of the double bond to give a 3H-oxazol-2-one derivative in excellent isolated yield.File in questo prodotto:
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