An efficient, solvent-free protocol for the N-fluorenylmethoxycarbonylation and N-benzyloxycarbonylation ofamines is described. The reaction of aliphatic and aromatic amines with FmocOSu and Cbz-Osu in [Bmim]-[BF4] at room temperature afforded the corresponding N-urethane derivatives in excellent yields and donot require any further purification. The method has been extended to the N-Fmoc and N-Cbz protectionof amino acids. Absence of bases, very short reaction times, high yields, selectivity and ease of productseparation are some advantages of this protocol
Scheda prodotto non validato
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo
Titolo: | N-Urethane protection of amines and amino acids in an ionic liquid |
Autori: | |
Data di pubblicazione: | 2015 |
Rivista: | |
Handle: | http://hdl.handle.net/20.500.11770/142785 |
Appare nelle tipologie: | 1.1 Articolo in rivista |