The selective synthesis of unsaturated N-acylethanolamines 1b-6b by lipase-catalyzed direct condensationbetween unsaturated fatty acids 1a-6a and ethanolamine is reported. Reactions were carried out in hexane at 40 °C, in thepresence of Candida antarctica Lipase B as the catalyst, to give the corresponding amides 1b-6b with yields ranging from80 to 88%.
Selective Synthesis of Unsaturated N-Acylethanolamines by Lipase-Catalyzed N-Acylation of Ethanolamine with Unsaturated Fatty Acids
GABRIELE, Bartolo;PLASTINA, Pierluigi
2009-01-01
Abstract
The selective synthesis of unsaturated N-acylethanolamines 1b-6b by lipase-catalyzed direct condensationbetween unsaturated fatty acids 1a-6a and ethanolamine is reported. Reactions were carried out in hexane at 40 °C, in thepresence of Candida antarctica Lipase B as the catalyst, to give the corresponding amides 1b-6b with yields ranging from80 to 88%.File in questo prodotto:
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