New data are constantly gathered to show the roleof oxidative stress and the involvement of reactive oxygenspecies in the pathogenesis of degenerative diseases. InsP6isable to coordinate iron metal in order to prevent iron catalyzed free radical formation. The aim of the present paper is to describe a new synthetic strategy in order to prepare apolymeric structure containing chemical functions able tocoordinate iron ions. Here, we report the synthesis of a copolymer containing phosphorylated myo-inositol groups and we evaluate its antioxidant efficiency. Such a system was synthesized by binding chemical groups susceptible of radical polymerization to myo-inositol. The synthesized monomer was copolymerized with N,N-dimethylacrylamide(DMAA) (molar ratio 1:3) and submitted to exhaustivephosphorylation. The reaction was proved by an assay speci-fic for phosphate groups. Finally, we evaluated the copolymer’s ability in inhibiting lipid peroxidation in rat livermicrosomal membranes. This study showed that the designed macromolecular system is particularly effective asantioxidant.

Synthesis and antioxidant efficiency of a new copolymer containing phosphorylated myo-inositol

Iemma F;Trombino S;Puoci F;Cirillo G;Spizzirri UG;Muzzalupo R;Picci N
2005

Abstract

New data are constantly gathered to show the roleof oxidative stress and the involvement of reactive oxygenspecies in the pathogenesis of degenerative diseases. InsP6isable to coordinate iron metal in order to prevent iron catalyzed free radical formation. The aim of the present paper is to describe a new synthetic strategy in order to prepare apolymeric structure containing chemical functions able tocoordinate iron ions. Here, we report the synthesis of a copolymer containing phosphorylated myo-inositol groups and we evaluate its antioxidant efficiency. Such a system was synthesized by binding chemical groups susceptible of radical polymerization to myo-inositol. The synthesized monomer was copolymerized with N,N-dimethylacrylamide(DMAA) (molar ratio 1:3) and submitted to exhaustivephosphorylation. The reaction was proved by an assay speci-fic for phosphate groups. Finally, we evaluated the copolymer’s ability in inhibiting lipid peroxidation in rat livermicrosomal membranes. This study showed that the designed macromolecular system is particularly effective asantioxidant.
antioxidants, copolymerization, lipid peroxidation, phosphorylated myo-inositol, radical polymerization
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11770/144882
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