It is of great significance to develop sustainable processes of catalytic reaction. We report a selective procedure for the synthesis of acetylated bioactive compounds in water. The use of 1‐acetylimidazole combined with Er(OTf)3as a Lewis acid catalyst gives high regioselectivity and good yields for the acetylation of primary hydroxyl groups, as well as amino groups. The protection is achieved in short reaction times under microwave irradiation, and is successful even in the case of base‐sensitive substrates.

Selective acetylation of small biomolecules and their derivatives catalyzed by Er(OTf)3

NARDI, Monica;Di Gioia, Maria Luisa
;
Costanzo, Paola;De Nino, Antonio;Maiuolo, Loredana;
2017

Abstract

It is of great significance to develop sustainable processes of catalytic reaction. We report a selective procedure for the synthesis of acetylated bioactive compounds in water. The use of 1‐acetylimidazole combined with Er(OTf)3as a Lewis acid catalyst gives high regioselectivity and good yields for the acetylation of primary hydroxyl groups, as well as amino groups. The protection is achieved in short reaction times under microwave irradiation, and is successful even in the case of base‐sensitive substrates.
Acetylation; Biomolecules; Catalysis; Catalysis; Physical and Theoretical Chemistry
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11770/264533
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 19
  • ???jsp.display-item.citation.isi??? 19
social impact