Aim:The CNP is component of natriuretic peptide family and have an important role in regulation of vascular tone. Is known the involvement of Ang II to release ANP and BNP in cardiac cell but not in the CNP release. We examined whether Ang II modulate CNP levels in human umbilical vein endothelial cells (HUVECs) and the contribution of the voltage operated calcium channel expressed in the endothelial cell: T-Type calcium channel (TCC) and L-Type calcium channel (LCC) which regulates the protein release. We further investigated the role of AT1 and AT2 receptors in this mechanism.
Voltage calcium channels are involved in Ang II-induced CNP release in Human Umbilical Vein endothelial Cells
Martini Aurela;Bruno Rosalinda;Mazzulla Sergio;NICOLETTA, VIRGILIA;Martino Guglielmo
2010-01-01
Abstract
Aim:The CNP is component of natriuretic peptide family and have an important role in regulation of vascular tone. Is known the involvement of Ang II to release ANP and BNP in cardiac cell but not in the CNP release. We examined whether Ang II modulate CNP levels in human umbilical vein endothelial cells (HUVECs) and the contribution of the voltage operated calcium channel expressed in the endothelial cell: T-Type calcium channel (TCC) and L-Type calcium channel (LCC) which regulates the protein release. We further investigated the role of AT1 and AT2 receptors in this mechanism.File in questo prodotto:
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