Epigallocatechin gallate (EGCG) was structurally modified to obtain EGCG fatty acid esters using an eco-friendly method employing Er(OTf)3 in 2-MeTHF as the catalyst. The products were purified in short times on a large scale using VERSAFLASH HTFP station on octadecyl-functionalized silica gel. The same Lewis acid showed to be a good catalyst for the synthesis of EGCG peracetated. The EGCG derivatives were assayed for their antioxidant capacity by DPPH assay and by ROS formation using the SH-SY5Y cell line.

Eco-friendly synthesis of lipophilic EGCG derivatives and antitumor and antioxidant evaluation

Nardi, Monica;Di Gioia, Maria Luisa;
2018

Abstract

Epigallocatechin gallate (EGCG) was structurally modified to obtain EGCG fatty acid esters using an eco-friendly method employing Er(OTf)3 in 2-MeTHF as the catalyst. The products were purified in short times on a large scale using VERSAFLASH HTFP station on octadecyl-functionalized silica gel. The same Lewis acid showed to be a good catalyst for the synthesis of EGCG peracetated. The EGCG derivatives were assayed for their antioxidant capacity by DPPH assay and by ROS formation using the SH-SY5Y cell line.
Antioxidants; EGCG; EGCG fatty acid esters; Log P; Neuroblastoma cells; Pharmacology; Drug Discovery3003 Pharmaceutical Science; Plant Science; Complementary and Alternative Medicine2708 Dermatology
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11770/290297
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