A convenient, 6-steps synthesis of the so far unknown trans-resveratrol-d4 7 (E-3',4,5'-trihydroxy-2,3,5,6-tetradeuterostilbene), starting from commercially available phenol-d6 1, with an overall yield of 25%, is described. The final labeled resveratrol was fully characterized by MS spectrometry and IR, 1H NMR, and 13C NMR spectroscopies. The isotopic distribution of the final product, determined by high resolution mass spectrometry, was as follows: d4, 96%; d3, 4%.
A convenient, six-step synthesis of the so far unknown trans-resveratrol-d(4), (E)-3',4,5'-trihydroxy-2,3,5,6-tetradeuterostilbene, starting from commercially available phenol-d(6), with an overall yield of 25%, is described. The final labeled resveratrol was fully characterized by MS, IR, and (1)H and (13)C NMR spectroscopy. The isotopic distribution of the final product, determined by high resolution mass spectrometry, was as follows: d(4), 96%; d(3), 4%. RI Di Donna, Leonardo/D-5707-2011
trans-Resveratrol-d4, a molecular tracer of the wild-type phytoalexin; synthesis and spectroscopic properties
Gabriele B.;Plastina P.;Fazio A.;Di Donna L.
2008-01-01
Abstract
A convenient, 6-steps synthesis of the so far unknown trans-resveratrol-d4 7 (E-3',4,5'-trihydroxy-2,3,5,6-tetradeuterostilbene), starting from commercially available phenol-d6 1, with an overall yield of 25%, is described. The final labeled resveratrol was fully characterized by MS spectrometry and IR, 1H NMR, and 13C NMR spectroscopies. The isotopic distribution of the final product, determined by high resolution mass spectrometry, was as follows: d4, 96%; d3, 4%.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
