The synthesis of a novel functional biomaterial for wound healing treatment wascarried out by adopting a free-radical grafting procedure in aqueous media. With this aim,ciprofloxacin (CFX) was covalently incorporated into collagen (T1C) chains employing anascorbic acid/hydrogen peroxide redox pair as biocompatible initiator system. The covalentinsertion of CFX in the polymeric chains was confirmed by FT-IR and UV analyses, whilean antibacterial assay demonstrated the activity of the synthesized conjugate againstStaphylococcus aureus and Escherichia coli, microorganisms that commonly infectwounds. A catechin blended conjugate was also tested in order to evaluate the ability toinfluence fibroblast cell growth. The observed antibacterial activity and stimulation of fibroblast growth support the applicability of CFX-T1C conjugate in wound treatmentencouraging the healing process.

Ciprofloxacin-collagen conjugate in the wound healingtreatment

Puoci F;Parisi OI;Cassano R;Trombino S;Curcio M;Iemma F;Cirillo G;Spizzirri UG;Restuccia D;Muzzalupo R;Picci N
2012

Abstract

The synthesis of a novel functional biomaterial for wound healing treatment wascarried out by adopting a free-radical grafting procedure in aqueous media. With this aim,ciprofloxacin (CFX) was covalently incorporated into collagen (T1C) chains employing anascorbic acid/hydrogen peroxide redox pair as biocompatible initiator system. The covalentinsertion of CFX in the polymeric chains was confirmed by FT-IR and UV analyses, whilean antibacterial assay demonstrated the activity of the synthesized conjugate againstStaphylococcus aureus and Escherichia coli, microorganisms that commonly infectwounds. A catechin blended conjugate was also tested in order to evaluate the ability toinfluence fibroblast cell growth. The observed antibacterial activity and stimulation of fibroblast growth support the applicability of CFX-T1C conjugate in wound treatmentencouraging the healing process.
protein, ciprofloxacin, quinolones, biomedical application, antibiotic,
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11770/138937
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact