Inflammation represents a condition most frequent in humans; often it’s underestimated making the problem an increasingly alarming phenomenon. For these reasons, conventional therapies are losing their effectiveness, leaving room for innovative therapies. In this field, natural products demonstrated their efficacy in various diseases; a flavonoid in particular, Quercetin, was here evaluated for its broad range of activity. In this review, we highlighted its efficacy in various models of inflammation, focusing also on the activity of its semisynthetic derivatives, and those naturally present in plant extracts. Finally, it was also evaluated its analgesic property, intrinsically linked to its anti-inflammatory action, to investigate about an innovative approach to this interesting natural compound such as analgesic remedial.

Quercetin and Derivatives: Useful Tools in the Inflammation and Pain Management

Gabriele Carullo;Anna Rita Cappello;Luca Frattaruolo;AIELLO, Francesca
2017-01-01

Abstract

Inflammation represents a condition most frequent in humans; often it’s underestimated making the problem an increasingly alarming phenomenon. For these reasons, conventional therapies are losing their effectiveness, leaving room for innovative therapies. In this field, natural products demonstrated their efficacy in various diseases; a flavonoid in particular, Quercetin, was here evaluated for its broad range of activity. In this review, we highlighted its efficacy in various models of inflammation, focusing also on the activity of its semisynthetic derivatives, and those naturally present in plant extracts. Finally, it was also evaluated its analgesic property, intrinsically linked to its anti-inflammatory action, to investigate about an innovative approach to this interesting natural compound such as analgesic remedial.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11770/154485
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