Polyunsaturated Fatty Acids (PUFAs) are a class of natural compounds with interesting biochemical effects on human health. Indeed, in addition to their beneficial effects in brain and cardiovascular disorders, ω-3 LC-PUFA supplementation can exert antineoplastic activity by triggering cell death in human cancer cells, either alone or in combination with conventional therapies. The aim of this review is, by analyzing the recent scientific literature, to highlight the molecular mechanisms of Omega-3Polyunsaturated Fatty Acids (ω-3 PUFAs) in antineoplastic events, and the effects of supplementing diets with them during chemotherapy regimens. This analysis may provide specific information to carry out future pre-clinical and clinical studies aimed at a better use of omega-3polyunsaturated fatty acids in cancer therapy.
Polyunsaturated Fatty Acids and their Role in the Diet of Cancer Patients: An Overview
Frattaruolo L;Aiello F;Carullo G;Fiorillo M;Brindisi M;Cappello AR
2018
Abstract
Polyunsaturated Fatty Acids (PUFAs) are a class of natural compounds with interesting biochemical effects on human health. Indeed, in addition to their beneficial effects in brain and cardiovascular disorders, ω-3 LC-PUFA supplementation can exert antineoplastic activity by triggering cell death in human cancer cells, either alone or in combination with conventional therapies. The aim of this review is, by analyzing the recent scientific literature, to highlight the molecular mechanisms of Omega-3Polyunsaturated Fatty Acids (ω-3 PUFAs) in antineoplastic events, and the effects of supplementing diets with them during chemotherapy regimens. This analysis may provide specific information to carry out future pre-clinical and clinical studies aimed at a better use of omega-3polyunsaturated fatty acids in cancer therapy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
