: Epidemiologic studies suggest that dietary polyphenol intake is associated with a lower incidence of several non‐communicable diseases. Although several foods contain complex mixtures of polyphenols, numerous factors can affect their content. Besides the well‐known capability of these molecules to act as antioxidants, they are able to interact with cell‐signaling pathways, modulating gene expression, influencing the activity of transcription factors, and modulating microRNAs. Here we deeply describe four polyphenols used as nutritional supplements: quercetin, resveratrol, epigallocatechin gallate (ECGC), and curcumin, summarizing the current knowledge about them, spanning from dietary sources to the epigenetic capabilities of these compounds on microRNA modulation.

Quercetin, epigallocatechin gallate, curcumin and resveratrol: from dietary sources to human microRNA modulation

Erika Cione;Chiara La Torre;Maria Cristina Caroleo;Pierluigi Plastina;
2020

Abstract

: Epidemiologic studies suggest that dietary polyphenol intake is associated with a lower incidence of several non‐communicable diseases. Although several foods contain complex mixtures of polyphenols, numerous factors can affect their content. Besides the well‐known capability of these molecules to act as antioxidants, they are able to interact with cell‐signaling pathways, modulating gene expression, influencing the activity of transcription factors, and modulating microRNAs. Here we deeply describe four polyphenols used as nutritional supplements: quercetin, resveratrol, epigallocatechin gallate (ECGC), and curcumin, summarizing the current knowledge about them, spanning from dietary sources to the epigenetic capabilities of these compounds on microRNA modulation.
nutrients, antioxidants, common use, phenolic compounds
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/20.500.11770/296920
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